Epigenetic Therapy in Human Choriocarcinoma
نویسندگان
چکیده
Because epigenetic alterations are believed to be involved in the repression of tumor suppressor genes and promotion of tumorigenesis in choriocarcinomas, novel compounds endowed with a histone deacetylase (HDAC) inhibitory activity are an attractive therapeutic approach. HDAC inhibitors (HDACIs) were able to mediate inhibition of cell growth, cell cycle arrest, apoptosis, and the expression of genes related to the malignant phenotype in choriocarcinoma cell lines. In this review, we discuss the biologic and therapeutic effects of HDACIs in treating choriocarcinoma, with a special focus on preclinical studies.
منابع مشابه
Pulmonary Metastatic Choriocarcinoma in a Patient with Ectopic Pregnancy
Gestational trophoblastic tumor (GTT) most commonly follows a molar pregnancy. In fact, it can occur following gestational events such as induced or spontaneous abortion, ectopic pregnancy, and term pregnancy. In this study, we present the case of a patient with ectopic pregnancy who was treated with a single dose of methotrexate (MTX). The maximum titer of beta subunit of human chorionic gonad...
متن کاملExpression of Concern: Takai, N. and Narahara, H. Epigenetic Therapy in Human Choriocarcinoma. Cancers 2010, 2, 1683–1688
We wish to make readers aware that text in [1] has been taken from other publications by the same author. In particular, much of Section 1, the first part of Section 2 and the first sentence of Section 3 are copied verbatim from [2]. Table 1 and the second part of Section 2 are taken from [3]. The main novel contribution of [1] lies in Section 3. We regret that these issues were not picked up b...
متن کاملCurcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation
BACKGROUND Cancer stem cells (CSCs), in choriocarcinoma and other carcinomas, possess the ability of self-renewal and multilineage differentiation potential. We previous isolated choriocarcinoma cancer stem-like cells (CSLCs), which hold the stemness characteristics of CSCs. Epigenetic modifications have emerged as drivers in tumorigenesis, but the mechanisms of CSCs are largely unknown, and ne...
متن کاملTrophoblast Biology, Biochemical Therapy and Prevention of Choriocarcinoma
Biochemical tumor marker was human chorionic gonadotropin (hCG) produced by choriocarcinoma itself, which was used to determine the complete remission of the carcinoma, which was treated by primary systemic methotrexate (MTX) therapy. Also, hCG was the marker of positive pregnancy test in the MTX prevention of choriocarcinoma. It will be important to use biochemical marker produced by the subje...
متن کاملHSPC117 Is Regulated by Epigenetic Modification and Is Involved in the Migration of JEG-3 Cells
The human hematopoietic stem/progenitor cell 117 (HSPC117) protein is an essential component of protein complexes and has been identified to be involved in many important functions. However, how this gene expression is regulated and whether the HSPC117 gene affects cell migration is still unknown. The aim of this study was to identify whether HSPC117 mRNA expression is regulated by epigenetic m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2010